DE SCIENCE DISCOVERY

Scientists develop gel that delivers drugs directly to diseased joints Osteoarthritis (OA) is a progressive condition affecting the lives of more than 32 million Americans. Post-traumatic osteoarthritis (PTOA), a major subset of osteoarthritis that comprises 10% of diagnoses and disproportionally affects injured military personnel, has no effective therapeutic protocols that slow or stop the progression except for over-the-counter analgesics. Post-traumatic osteoarthritis leads to articular cartilage damage and results in more than $3 billion in health care costs each year. researchers based at New York University identified the molecular mechanism and therapeutic payload for delivering pharmacologic treatment directly to affected joints, effectively halting the onset and progression of post-traumatic osteoarthritis The researchers combined compounds to develop a porous gel that can reach and envelop affected joints, reduce inflammation and induce regeneration. The substanc...

Scientists identify neurons in the brain that drive competition and social behavior within groups New research in mice has identified neurons in the brain that influence competitive interactions between individuals and that play a critical role in shaping the social behavior of groups. Published in Nature by a team led by investigators at Massachusetts General Hospital (MGH), the findings will be useful not only for scientists interested in human interactions but also for those who study neurocognitive conditions such as autism spectrum disorder and schizophrenia that are characterized by altered social behavior. "Social interactions in humans and animals occur most commonly in large groups, and these group interactions play a prominent role in sociology, ecology, psychology, economics and political science," says lead author S. William Li, an MD/PhD student at MGH. "What processes in the brain drive the complex dynamic behavior of social groups remains poorl...